WebApr 13, 2024 · Phthalocyanines (Pcs) and their derivatives are promising second-generation photosensitizers owing to their extraordinary properties such as strong absorption in the near-infrared region, photostability, and high ROS quantum yield ( … WebWe applied colorimetric assay to determine the cytotoxicity of the compounds; flow cytometry to analyze the production of reactive oxygen species (ROS), cell cycle, and mitochondrial membrane potential (MMP); immunochemistry to study protein expression; and colony forming assay to evaluate changes in radiosensitivity.
Cytotoxic and Antitumor Activity of Sulforaphane: The …
WebSecond, a potent increase in reactive oxygen species was observed upon treatment with the selected ferrocenes. This can be explained by the basic chemical structure of the … Reactive oxygen species (ROS) with the potential to cause cellular damage are produced along with the release of energy. ROS can damage lipids, DNA, RNA, and proteins, which, in theory, contributes to the physiology of aging. ROS are produced as a normal product of cellular metabolism. See more In chemistry, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen (O2). Examples of ROS include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen See more Effects of ROS on cell metabolism are well documented in a variety of species. These include not only roles in apoptosis (programmed cell … See more Exposure of spermatozoa to oxidative stress is a major causative agent of male infertility. Sperm DNA fragmentation, caused by oxidative stress, appears to be an important factor … See more Endogenous sources ROS are produced by biochemical reactions that occur during the processes of respiration and … See more Superoxide dismutase Superoxide dismutases (SOD) are a class of enzymes that catalyzes the dismutation of superoxide into … See more According to the free radical theory of aging, oxidative damage initiated by reactive oxygen species is a major contributor to the … See more ROS are constantly generated and eliminated in the biological system and are required to drive regulatory pathways. Under normal physiological conditions, cells control ROS levels by balancing the generation of ROS with their elimination by scavenging … See more dworkin a matter of principle 1985
Dual‐Modulated Release of a Cytotoxic Photosensitizer …
WebPeroxynitrite is a key macrophage-derived cytotoxic agent released to the phagosomes of activated macrophages upon T. cruzi invasion and promotes protein tyrosine ... I … WebReactive oxygen species are the major antibacterials against SalmonellaTyphimurium purine auxotrophs in the phagosome of RAW 264.7 cells Radha K. R. Mantena, Radha K. R. Mantena Department of Microbiology and Immunology, The University of Melbourne, Vic. 3010, Australia. Australian Bacterial Pathogenesis Program, Melbourne, Victoria, Australia. WebThe cytotoxic effect of juglone can be attributed to mechanisms including the induction of oxidative stress, cell membrane damage, and a clastogenic action leading to cell death by both apoptosis and necrosis. All Science Journal … dworkin and maciariello fax