WebPTEN Full Name Phosphatase and tensin homolog Alternative Names PTEN; Phosphatase and tensin homolog Gene ID 5728 (Human); 19211 (Mouse); 50557 (Rat) Uniprot ID P60484 (Human); O08586 (Mouse) Related Products Neural Antibodies Mouse Anti-PTEN Monoclonal Antibody (5C10B6), Unconjugated (CAT#: NAB20101734CR) Web28 Sep 2009 · The tumour suppressor gene, phosphatase and tensin homolog ( PTEN ), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in human tumour cells.
About Mutations in the PTEN Gene - Memorial Sloan Kettering …
Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies have found increased frequency of PTEN loss in tumours which are more … See more Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the inositol ring in PIP3, resulting in the biphosphate … See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more Web10 Apr 2024 · We assessed the dose-dependent effects of a MOSAICS vector containing an sgRNA against Pten. We injected MOSAICS AAV8-sg Pten into doxycycline (dox)-inducible TetO-Cas9 mice to generate somatic mutations in the liver and into LSL-tdTomato mice to monitor the expression of SB100-P2A-Cre protein, which activates Tomato ( Figure 2 B). how to paint ceramic vase another color
Conserved synteny between the Fugu and human PTEN …
WebApplications: ELISA: Reactivity: Human: Note: FOR RESEARCH USE ONLY (RUO). Sensitivity: 0.136ng/mL: Detection Limit: 0.312-20ng/mL: Short Description: This PTEN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma … Web8 Nov 2004 · This is the first report on the PI3K/PTEN-AKT-mTOR pathway in common human tumors and evaluation of the coordinated expression of different signaling proteins, which should provide a useful tool for selecting future targeted phase II and III clinical trials in the development of this exciting class of agents. my 600 pound life henry story