Tirapazamine pubchem
WebTirapazamine ≥98% (HPLC) Synonym (s): 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine, SR 259075, SR 4233, Tirazone, Win 59075 Empirical Formula (Hill Notation): … Tirapazamine (SR-[[4233]]) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia. Thus, tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by radiotherapy and …
Tirapazamine pubchem
Did you know?
WebTirapazamine, also known as SR-4233, is a hypoxia-activated antitumor agent. 1-3) It is converted to the reactive one-electron reduction product (radical anion) under hypoxic … WebUnder hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin. Safety Information Piktogramme GHS07 Signalwort Warning H-Sätze
Web1 feb 2006 · Tirapazamine (TPZ, 3‐amino‐1,2,4‐benzotriazine 1,4‐dioxide), a representative hypoxia‐activated prodrugs (HAPs), has entered Phase II/III clinical trials. Web29 lug 2024 · Tirapazamine (SR-4233, WIN 59075) [3-amino-1,2,4-benzotriazine-1,4 dioxide], the first hypoxia-activated prodrug, was reported in 1986 ( 12 ). Through one-electron reduction, the prodrug can generate an oxidative radical, which will diffuse into hypoxic regions and cause oxidative damage ( 13) ( Figure 2 ).
WebTirapazamine is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen . Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia. Thus, tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by … Web2 gen 2024 · Chemsrc provides Tirapazamine(CAS#:27314-97-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tirapazamine are …
Web19 ott 2007 · Tirapazamine, also known as SR-4233, is an experimental anticancer drug that is activated in hypoxic conditions. This activation is very useful as this hypoxic …
WebTirapazamine ≥98% (HPLC) Synonym (s): 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine, SR 259075, SR 4233, Tirazone, Win 59075 Empirical Formula (Hill Notation): … emotion words for angerWeb0 CarotenoidsDatabase A Database of information on naturally occurring carotenoids from many organisms extracted from the literature. 0 NMRShiftDB NMRShiftDB is a NMR … emotion words cards free printableWebMoreover, the increased anticancer efficacy of tirapazamine combined with irinotecan was further validated in a human liver cancer Bel-7402 xenograft mouse model. Taken together, our data show for the first time that HIF-1α is strongly correlated with resistance to topoisomerase I inhibitors in hepatocellular carcinoma. emotion word wallWebTirapazamine 27314-97-2 東京化成工業株式会社 CAS RN: 27314-97-2 製品コード: T3823 Tirapazamine 純度（試験方法）: >98.0% (HPLC) 別名: チラパザミン 3-アミノベンゾ [ e ] [1,2,4]トリアジン 1,4-ジオキシド SR 259075 3-Aminobenzo [ e ] [1,2,4]triazine 1,4-Dioxide ドキュメント： SDS 規格表 試験成績書・各種証明書検索 分析チャート 大 … emotion words starting with aWebPubChem 识别号. 33776. 存放 ... Chemical Structure - Tirapazamine, cytotoxic agent (ab141976) 2D chemical structure image of ab141976, Tirapazamine, cytotoxic agent. emotion words for writersWebTirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide or SR 4233) is a cytotoxic drug with selective toxicity towards hypoxic mammalian cells. Under both aerobic and hypoxic … emotion words with definitionsWebProduct name Tirapazamine, cytotoxic agent Description Potent cytotoxic agent Biological description Potent cytotoxic agent. Induces apoptosis due to breaks in single and double … dr andrew catalone auburn ny